I am looking for a story,

Magical? gender change, Grandmother dying, mother last of the matriarchal clan, son changed.

I say "magical?" as I cannot remember if magic is involved

I can however remember the clan is a clan of were's and they are big cats, Lion, Tiger, Puma, Panther type big cat.

I think he gets injured in a car accident, before change

also I seem to remember he was at college/university studying forensics (CSI), which also helps when members of another clan in the town begin to reappear dead